Transactivation of Cxcr4 by Igf-1r in Human Mda-mb-231 Breast Cancer Epithelial Cells
نویسندگان
چکیده
CANCER EPITHELIAL CELLS. Chareeporn Akekawatchai, Jane D. Holland, Marina Kochetkova, John C. Wallace and Shaun R. McColl. From the School of Molecular and Biomedical Science, the University of Adelaide, Adelaide, South Australia, Australia, 5005. Running Title: Transactivation of CXCR4 by IGF-1 Address correspondence to: Professor Shaun McColl, Head, Chemokine Biology, School of Molecular and Biomedical Science, the University of Adelaide, Adela ide, South Australia, Australia, 5005. Tel. 618 8303 4259; Fax 618 8303 3337; E-mail: [email protected]
منابع مشابه
Interfering with CXCR4 expression inhibits proliferation, adhesion and migration of breast cancer MDA-MB-231 cells
To investigate the effect and mechanism of the CXC chemokine receptor 4 (CXCR4) in the proliferation and migration of breast cancer, a short-hairpin RNA (shRNA) eukaryotic expression vector targeting CXCR4 was constructed, and the impact of such on the proliferation, adhesion and migration of human breast cancer MDA-MB-231 cells was observed. The fragments of CXCR4-shRNA were synthesized and cl...
متن کاملMiR-99a suppress proliferation, migration and invasion through regulating insulin-like growth factor 1 receptor in breast cancer.
OBJECTIVE Breast cancer is one of the most common malignant tumors in women. Despite the advances made in treatments of breast cancer, the incidence and death rates of breast cancer are still on the rise. Therefore, it is essential for us to explore the potential mechanism accounting for the malignancy of breast cancer. MATERIALS AND METHODS A lentiviral vector over-expressing miR-99a in MDA-...
متن کاملThe Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines
It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...
متن کاملInsulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells
The expression of epidermal growth factor receptor (EGFR) is an important diagnostic marker for triple-negative breast cancer (TNBC) cells, which lack three hormonal receptors: estrogen and progesterone receptors as well as epidermal growth factor receptor 2. EGFR transactivation can cause drug resistance in many cancers including TNBC, but the mechanism underlying this phenomenon is poorly def...
متن کاملThe Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines
It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...
متن کامل